A synthetic progestin called medroxyprogesterone could help with several hormonal and gynaecological problems. It influences the endometrium, menstrual cycle, and fertility by reproducing the activities of progesterone. It may help with endometriosis, amenorrhea, and unusual uterine bleeding. It could also help males going through hormone replacement therapy.

Medroxyprogesterone mimics the effects of natural progesterone in the body. It binds to progesterone receptors, helping to regulate hormonal signals that control menstruation and maintain the uterine lining. By stabilizing hormone levels, it prevents excessive uterine bleeding and helps restore normal menstrual cycles. Additionally, it influences the hypothalamus and pituitary gland, reducing the secretion of certain hormones that trigger ovulation, thus aiding in reproductive management.

This medication should not be used by individuals with known allergies to medroxyprogesterone or its ingredients. It is contraindicated in cases of unexplained vaginal bleeding, certain types of cancers (such as breast or uterine cancer), liver disease, or blood clotting disorders. Before starting the treatment, a thorough medical evaluation is recommended. Patients with a history of stroke, heart disease, or high blood pressure should use it cautiously under medical supervision.

Medroxyprogesterone may interact with other medications, including anticoagulants, corticosteroids, and certain antibiotics, which could alter its effectiveness or increase side effects. Drugs that affect liver enzymes, like rifampin or anticonvulsants, may reduce its efficacy. It’s important to inform your healthcare provider about all medications, supplements, and herbal products you are using to avoid unwanted interactions.

Some individuals may experience changes in menstrual flow, weight gain, or bloating. Less frequently, it may cause dizziness, fatigue, or acne. In rare cases, serious reactions such as blood clots, severe allergic responses, or liver issues may occur, and medical attention should be sought immediately if symptoms worsen or unusual signs appear.

Medroxyprogesterone is generally not recommended during pregnancy unless specifically prescribed for medical reasons, as it may interfere with normal hormonal development. If pregnancy is suspected while taking this medication, it should be discontinued, and a healthcare provider should be consulted. While breastfeeding, medroxyprogesterone may pass into breast milk and could affect the nursing infant, so it should only be used when clearly needed and after discussing risks and benefits with a healthcare professional.

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

1. Sathe A, Patel P, Gerriets V. Medroxyprogesterone. [Updated 2024 Feb 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559192/– LinkOpens in New Tab
2. “Medroxyprogesterone: Uses, Side Effects, Interactions & Warnings.” WebMD, webmd.com/drugs/2/drug-8674/medroxyprogesterone-oral/details