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Nandrolone decanoate is given as a deep intramuscular injection, most often into the buttock muscle. A healthcare professional typically administers the dose, though trained patients or caregivers may sometimes give the injection. The dosage varies depending on the condition being treated, the patient’s response, and tolerability. For example, men with anemia from chronic kidney disease may receive 100–200 mg weekly, while women are given 50–100 mg. In cases like muscle wasting or bone loss, doses between 50–200 mg every 1–4 weeks are common. Treatment is often intermittent to reduce long-term risks, and therapy duration depends on patient needs and improvements. Pediatric use is rare and limited, with much lower doses due to the risk of affecting bone growth. The drug is supplied as a sterile oil-based solution, and each vial must be checked for clarity and contaminants before use. Regular blood tests, liver function checks, and hormonal monitoring guide therapy, ensuring safety and effectiveness. Adequate nutrition is essential to support the anabolic benefits. Providers aim to use the minimum effective dose and continually assess treatment benefits versus risks throughout the course of therapy.
Nandrolone Decanoate Injection is an anabolic steroid commonly prescribed to treat conditions such as severe weight loss, muscle wasting diseases, and certain forms of anemia. It helps enhance muscle mass, improve strength, and support recovery in patients who struggle to maintain body weight or muscle due to illness or injury. This medication is used under strict medical supervision because of its potent effects and the possibility of unwanted side effects if misused.
Nandrolone Decanoate works by mimicking the effects of naturally occurring androgens like testosterone. It promotes protein synthesis within muscle cells, aiding in tissue repair and muscle growth. It also encourages nitrogen retention, which is essential for building and maintaining muscle mass. Additionally, nandrolone supports bone density and red blood cell production, helping to enhance physical strength and endurance, particularly in patients with chronic health conditions.
This medication should not be used in individuals with prostate or breast cancer, liver disease, heart problems, or untreated high blood pressure. It is also contraindicated in pregnancy due to its potential harm to fetal development. Caution is necessary in patients with kidney issues, diabetes, or a history of hormone-sensitive tumors. Regular medical checkups, including liver and cardiovascular assessments, are crucial to ensure that the medication is being used safely.
Nandrolone Decanoate may interact with medications such as anticoagulants, insulin, and corticosteroids. These interactions can influence blood clotting, hormone levels, and blood sugar control. Using other anabolic steroids or performance-enhancing supplements at the same time can amplify side effects like liver strain or hormonal imbalances. It’s important to inform your healthcare provider about all prescription drugs, over-the-counter medicines, and supplements you are taking before starting treatment.
Common side effects include fluid retention, headache, increased blood pressure, and changes in mood or libido. Some patients may experience acne, oily skin, or hair growth in unusual areas. In men, long-term use can lead to breast enlargement, testicular shrinkage, and reduced sperm production, while women may notice voice deepening, irregular periods, or facial hair growth. Rare but serious complications include liver toxicity and cardiovascular problems. Any unexpected symptoms should be reported immediately.
Nandrolone Decanoate is strictly avoided during pregnancy because it can disrupt normal fetal development and lead to birth defects. Women who are breastfeeding should not use this medication, as it may transfer through breast milk and affect the baby’s hormonal balance and growth. Safer treatment alternatives should be discussed with a healthcare provider to ensure the health and well-being of both mother and child.
Proper storage and handling of nandrolone decanoate injection are important to maintain its stability and sterility. The multi-dose vials should be stored at controlled room temperature, typically around 20°-25°C (68°-77°F). Excursions outside this range should be minimized; the compound should not be frozen, and it is best kept in a cool, dry place. The vials must be protected from light. Nandrolone decanoate solution is light-sensitive, and exposure to direct light could potentially degrade the active ingredient over time. For this reason, the medication is often dispensed in amber-colored vials or kept within its carton until ready for use. Users should keep the vial in its original packaging when not in use and store it away from sunlight or strong artificial light.
Because this is a compounded sterile preparation, it will have a beyond-use date (BUD) assigned by the pharmacy rather than a manufacturer’s expiration date. The BUD indicates how long the vial’s contents remain stable and sterile under recommended storage conditions. Patients should note the BUD on the label and not use the medication beyond that date. Once the BUD or expiration is reached, any unused solution should be disposed of properly.
The vial should be stored out of reach of children and pets for safety. When handling the vial, users should inspect it for any cracks or damage before each use, as compromised vials could lead to contamination. Syringes and needles used to withdraw and inject the solution should be sterile and preferably used only once (needles should never be re-entered into the vial with a non-sterile needle). If multiple doses are drawn from the same vial over time, the rubber stopper should be swabbed with an appropriate antiseptic (e.g. isopropyl alcohol) before each puncture to maintain sterility.
If the solution appears cloudy, has precipitated (crystals), or shows particles, do not use it and contact the pharmacy. Nandrolone decanoate in solution is usually a clear to yellowish oily liquid; any marked change in appearance could indicate contamination or instability. Likewise, if a vial develops an unusual odor or if there is any suspicion it may have been contaminated or stored improperly, it should be discarded according to medical waste protocols.
Disposal of unused or expired anabolic steroid medication should follow state and federal guidelines for controlled substances. Patients should not simply throw vials in the trash or flush them. Instead, return programs or consultation with the pharmacy for safe disposal methods are recommended due to the medication’s hormonal activity and controlled status.
In summary, store nandrolone decanoate vials at room temperature in a light-protected environment, observe the beyond-use date, and handle the vial with sterile technique. By adhering to these storage and handling recommendations, the potency and sterility of the medication are maintained for the duration of its use.
- Cleveland Clinic. (n.d.). Nandrolone. In Cleveland Clinic Health Library. Retrieved May 3 2025, from https://my.clevelandclinic.org/health/drugs/24940-nandrolone – LinkOpens in New Tab
- Hassan, D. A. E., Imam, H., Zidan, N., et al. (2023). The toxic effects of anabolic steroids “nandrolone decanoate” on cardiac and skeletal muscles with potential ameliorative effects of silymarin and fenugreek in rats. BMC Pharmacology and Toxicology, 24(1), 17. https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-023-00658-x – LinkOpens in New Tab
- Patanè, F. G., Liberto, A., Maglitto, A. N. M., et al. (2020). Nandrolone decanoate: Use, abuse and side effects. Medicina (Kaunas), 56(11), 606. https://doi.org/10.3390/medicina56110606 – LinkOpens in New Tab
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- American Regent, Inc. (2010). Nandrolone Decanoate Injection, USP – Package Insert. Shirley, NY: American Regent Pharmaceuticals. Retrieved Mar 25 2025, from https://www.drugs.com/pro/nandrolone.html
