Niacin, a form of vitamin b3, is critical for the body’s energy metabolism.^[1] Beyond potential metabolic functions, niacin may have antidyslipidemic properties, making it a potential option for the management of dyslipidemia and related cardiovascular disorders.^[2]

Furthermore, niacin serves as a precursor to nicotinamide adenine dinucleotide (NAD), an essential coenzyme involved in various cellular processes, including energy production and regulation of gene expression.^[1] Through conversion to the metabolically active NAD, niacin assists with the maintenance of cellular integrity and function, potentially impacting a wide range of physiological functions, from metabolism to cellular signaling and oxidative stress management.^[1]

Niacin is a vasodilator, meaning it may help widen blood vessels, which in turn may assist with improving blood flow.^[3] This may result in flushing, particularly in the face, neck or chest.^[3][4]

Some sustained-release forms of niacin may have lower reported flushing but may have increased risk of liver toxicity compared to immediate-release forms.^[4]

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

1. National Institutes of Health (NIH) Office of Dietary Supplements. Niacin – Health Professional Fact Sheet. Available from: https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/– LinkOpens in New Tab
2. “Niacin.” MedlinePlus, U.S. National Library of Medicine, medlineplus.gov/druginfo/meds/a682518.html.
3. “Niacin.” PubChem, National Center for Biotechnology Information, pubchem.ncbi.nlm.nih.gov/compound/Niacin.
4. Niacin, Niacinamide. Clinical Pharmacology powered by ClinicalKey. Elsevier. Updated May 14, 2024. Accessed June 25, 2024. https://www.clinicalkey.com/pharmacology/monograph/1473?sec=mondesc