Vitamin B-Complex Injection (B1 / B2 / B3 / B5 / B6) (30 mL Vial)

Among many other physiological processes including energy production, DNA/RNA synthesis and repair, methylation activities, and the synthesis of neurochemicals and signaling compounds, vitamin B complex is essential. Since humans cannot manufacture these watersoluble vitamins, constant intake is crucial; they naturally coexist in comparable foods. Other health problems and chronic neurological diseases might result from deficiency. Common causes of deficiency include excessive alcohol intake, bad gastrointestinal absorption, liver malfunction, and heavy consumption of processed foods free of dairy and meat.

Parenteral administration (intramuscular or intravenous) of vitamin B complex is preferred in emergencies since it avoids first-pass metabolism, provides dependable therapeutic levels, and improves bioavailability. Particularly when oral intake is impracticable.

Usually found in pharmaceutical formulations are:

Thiamine hydrochloride (vitamin B1) 100 mg
Riboflavin5Phosphate Sodium, 2 mg
100 mg vitamin B3 (niacinamide)
Dexpanthenol 2 mg, vitamin B5
Among the jobs of particular B vitamins are:

It helps avoid type 2 diabetes, heart disease, kidney problems, vision abnormalities, and neurodegenerative illnesses including Alzheimer’s.

Strong antioxidant, vitamin B2 (riboflavin helps to maintain healthy blood cells and speed metabolism.

Dexpanthenol, also known as vitamin B5, helps the central nervous system, energy production, and synthesis of amino acids, blood cells, vitamin D, and fatty acids.

Key in neurotransmitter synthesis, mental health, immune function, amino acid metabolism, and the folate cycle; deficiency can cause anemia. Vitamin B6 (Pyridoxine).

Epidemiological studies indicate that typical suggested dosages mostly stop marginal deficiencies and that higher doses might offer more health advantages.

Although B vitamins have distinct purposes, their roles are interconnected and complementary. By producing holoenzyme, they serve as coenzyme in numerous biochemical processes to activate enzyme reaction of related protein. Participating as holoenzyme, they support most cell functions.

The total participates more actively in the methionine cycle and citric acid cycle, which is the mitochondrial energy generation process, but vitamin B1 and B6’s contributions are greater. Successful implementation of it depends on vitamin B group. Maintaining the health of the nervous system also relies on B vitamins as they are essential for the operation of both the peripheral nervous system and the central nervous system.

In the pentose phosphate pathway of glycolysis, vitamin B1 (thiamine) acts as a coenzyme with transketolase enzyme. This route transforms glucose to ribulose5phosphate by retrieving the carbon from the pentose to produce pentose sugar for amino acid and nucleic acid synthesis. phosphate shunt. Many biologically significant redox processes including energy producing, biosynthetical, detoxifying and electron scavenging pathways depend greatly on vitamin B2 (riboflavin). a forerunner of coenzyme flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). As a cofactor for methionine synthase reductase (MTRR) and methylenetetrahydrofolate reductase (MTHFR), riboflavin is also critical for the metabolism of homocysteine.

Vitamin B3 (Niacin) aids in the synthesis of acetylCoA in the citric acid cycle, but NAD+ (nicotinamide) converts its coenzyme. In the anabolic methionine cycle, niacin—in the form of NAD—is a crucial cofactor for the enzymes dihydrofolate reductase in Sadenosylhomocysteine hydrolase and the folate/tetrahydrobiopterin cycle. At least 70 enzymes use coenzyme A for metabolism. It also participates in the synthesis of several neural messengers.

Acting as an essential cofactor in the folate cycle, vitamin B6 (pyridoxine) combines with serine hydroxymethyl transferase to cause the conversion of tetrahydrofolate (THF) to 5,10 methylene THF. B6 is a rate limiting cofactor in the synthesis of several neurotransmitters such as dopamine, serotonin, γaminobutyric acid (GABA), noradrenaline and the hormone melatonin.

To avoid speed reactions, intravenous vitamin B formulations should be given gently and, if necessary, the medication should be diluted. To avoid extreme reactions, the patient should be asked in depth regarding any symptoms from earlier doses. A skin sensitivity test should be conducted before to use. For older patients (60+ years), particularly those with arteriosclerosis, one must always consider the possibility of circulatory collapse following administration.

Some antidepressants used with vitamin B complex might cause terror, therefore pointing to a possible impact of these vitamins on central nervous system. Reports on the riboflavin injections were received.

Earlier reports have described anaphylactic shock from intravenous vitamin B complex use.

Particularly if the patient is allergic to thiamine hydrochloride, or vitamin B1, in the composition is known to cause life-threatening anaphylaxis on several doses. Less dangerous responses to B1 include stomach pain, nausea, pruritus, anxiety, and respiratory distress. Overdose syndromes include vomiting, anorexia, headache, irritability, tremors, and palpitations.

Although unusual, side effects from vitamin B2 in the formulation call for skin testing or when needed the more sensitive intradermal skin test can be recommended to detect anaphylactic sensitivity.

Larger doses of niacin usually bring on vomiting and nausea. As nicotinic acid in the blood stream, it can produce skin flush; this response is actually accountable for the acceptable upper limit (UL) for For adults in the United States, niacin at 35 mg per day.

Reportedly causing a life-threatening negative reaction of eosinophilic pleuropericarditis, vitamins B5 and H call for a patient history for such allergy before application.

Extended B6 overuse (150200 mg/day) spanning weeks can result in severe sensorynervoussystem dysfunction and ataxia.With conventional use, pyridoxine has not been linked to any major side effects. In some cases, however, diarrhea, emesis, and rosacealike dermatitis may be noted. (vitamin B6)

Typically advised during pregnancy according to individual needs are B group vitamins. No particular safety data could be found. Before usage, a doctor should counsel patients.

Generally advised during breastfeeding according to personal requirements, B-group vitamins. These vitamins go through the breast milk to the baby. No particular safety information could be found. The doctor’s pre-use advice is advised.

Store this medication in a refrigerator at 36°F to 46°F (2°C to 8°C). Keep all medicines out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

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