7-Keto DHEA Capsule (Each)

A promising substitute for maintaining metabolism and aging is 7keto DHEA.

The most prevalent steroid in the blood, DHEA itself has been investigated for possible advantages in aging and other medical problems. But because DHEA can change into male and female sex hormones like testosterone and oestrogen, it occasionally results in undesired adverse effects like hormonal imbalances or masculinization in women. 7ketoDHEA provides an appealing substitute here; it helps some of the advantages associated with DHEA without transforming into these sex hormones.

Interestingly, concentrations of this molecule are comparable in both men and women and change dramatically depending on age as well as other variables. Consequently, others think that supplementing with 7ketoDHEA might help the body keep energy levels and encourage a more youthful state, especially in individuals with low DHEA levels.

Once eaten, the body rapidly transforms it into a sulfate type readily usable by the body.

Studies indicate that 7ketoDHEA can increase metabolism and assist patients in shedding pounds. Overweight volunteers in monitored trials who took the supplement lost more weight than those assigned a placebo. 7ketoDHEA elevated resting metabolic rate, hence assisting subjects in burning more calories throughout the day, when combined with a calorierestricted diet, according another research.

7ketoDHEA seems to provide metabolic and weight control assistance generally without the hormonal side effects linked with DHEA. For individuals seeking to raise energy levels, encourage healthy aging, or keep a healthy body weight, it may be especially helpful.

Increasing resting metabolic rate, 7 keto DHEA is thought help with weight management or loss. Studies in preclinical animal models revealed that 7ketoDHEA on a molecular level boosted the activity of thermogenesis-related enzymes including mitochondrial and cytosolic snglycerol3phosphate dehydrogenase and cytosolic malic enzyme. It also accelerated mitochondrial substrate oxidation as well as enzyme activity participating in fatty acid oxidation including liver catalase and fatty acylCoA oxidase. Though it is thought the metabolites of 7ketoDHEA, 7αOHDHEA and 7βOHDHEA, might play a part, how 7ketoDHEA helps to produce these changes is unknown.

7αOHDHEA and 7βOHDHEA could also mediate some of the other effects of DHEA and 7ketoDHEA, including enhanced immune response. Both 7αOHDHEA and 7βOHDHEA have been found to prevent human skin from converting cortisone to cortisol; however, 7βOHDHEA was seven times more powerful than 7αOHDHEA. Therefore, one could hypothesize that their function as anti glucocorticoids helps to explain some of the physiological activity of 7ketoDHEA and its metabolites. But because cortisol and cortisone are found in much greater concentrations than 7αOHDHEA and 7βOHDHEA, these 7ketoDHEA metabolites might not have a systemic impact. They can, however, act locally via autocrine or paracrine mechanisms in tissues.

T3 may rise with 7ketoDHEA.

Before starting this medicine, persons with low blood pressure should see a doctor.

SevenketoDHEA had no other known contraindications or cautions as of writing. This product should not be used by those with established dually allergic reaction to any of the capsule constituents or DHEA.

bite, vertigo, and high serum triiodothyronine (T3) levels. Seven-keto-DHEA showed no negative effects in brief investigations in preclinical models. Administered as 3βacetyl7oxoDHEA, short-term human trials on 7ketoDHEA are safe and well tolerated. The long-term safety of 7ketoDHEA, in whatever form, or its metabolites has not been investigated.

Eighty-two percent of the 16 participants in the 7ketoDHEA group and all those (n=6) in the placebo group reported little negative effects in this study of twenty-two healthy male individuals. Gastrointestinal disturbance was the most frequent negative effect; it affected 18% of the 7ketoDHEA patients and 33% of the placebo recipients. Headaches (n=4) were noted in the 7ketoDHEA group. Two unfavorable effects were thought of as maybe linked to 7ketoDHEA treatment: reduced hematocrit and hemoglobin levels (n=1) and increased mosquito bite sensitivity (n=1). Participants who got the 7ketoDHEA acetyl ester also had far lower blood pressure during treatment than their starting levels.

Other negative effects and side effects linked to 7ketoDHEA supplementation include nausea and dizziness as well as elevated serum triiodothyronine (T3) levels, respectively.

In pregnant women, the safety of 7ketoDHEA has not been assessed. Pregnant women should stay away from 7ketoDHEA because of the paucity of safety information available.

In children and women who are breastfeeding, the safety of 7ketoDHEA has not been assessed. Because of this lack of safety information, moms nursing and children should stay away from 7ketoDHEA.

1. National Center for Biotechnology Information. PubChem Compound Summary for CID 193313, 7-Keto-dehydroepiandrosterone. https://pubchem.ncbi.nlm.nih.gov/compound/7-Keto-dehydroepiandrosterone.– LinkOpens in New Tab Accessed July 29, 2020.
2. Lardy H, Partridge B, Kneer N, Wei Y. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proc Natl Acad Sci U S A. 1995;92(14):6617-6619. doi:10.1073/pnas.92.14.6617
3. Lardy H, Kneer N, Wei Y, Partridge B, Marwah P. Ergosteroids. II: Biologically active metabolites and synthetic derivatives of dehydroepiandrosterone. Steroids. 1998;63(3):158-165. doi:10.1016/s0039-128x(97)00159-1
4. Samaras N, Samaras D, Frangos E, Forster A, Philippe J. A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: is treatment beneficial? Rejuvenation Res. 2013;16(4):285-294. doi:10.1089/rej.2013.1425
5. Robinzon B, Michael KK, Ripp SL, Winters SJ, Prough RA. Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11β-hydroxysteroid dehydrogenases? Arch Biochem Biophys. 2003;412(2):251-258. doi:10.1016/S0003-9861(03)00056-0
6. Davidson M, Marwah A, Sawchuk RJ, et al. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med. 2000;23(5):300-310. https://www.ncbi.nlm.nih.gov/pubmed/11055323– LinkOpens in New Tab
7. Accessed August 3, 2020.
8. Muller C, Pompon D, Urban P, Morfin R. Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2006;99(4-5):215-222. doi:10.1016/j.jsbmb.2005.12.001
9. Kazihnitková H, Zamrazilová L, Hill M, Lapcík O, Pouzar V, Hampl R. A novel radioimmunoassay of 7-oxo-DHEA and its physiological levels. Steroids. 2007;72(4):342-350. doi:10.1016/j.steroids.2006.12.005
10. Marenich LP. Excretion of testosterone, epitestosterone, androstenedione and 7-keto-dehydroepiandrostenedione in healthy men of different ages. Probl Endokrinol (Mosk). 1979;25(4):28-31. https://www.ncbi.nlm.nih.gov/pubmed/157483– LinkOpens in New Tab
11. Accessed August 7, 2020.
12. Orentreich N, Brind JL, Rizer RL, Vogelman JH. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab. 1984;59(3):551-555. doi:10.1210/jcem-59-3-551
13. National Center for Biotechnology Information. 7-Oxodehydroepiandrosterone 3-acetate | C21H28O4 – PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/7-Oxodehydroepiandrosterone-3-acetate.– LinkOpens in New Tab Accessed August 3, 2020.
14. Worrel ME, Gurkovskaya O V, Leonard ST, Lewis PB, Winsauer PJ. Effects of 7-keto dehydroepiandrosterone on voluntary ethanol intake in male rats. Alcohol. 2011;45(4):349-354. doi:10.1016/j.alcohol.2010.08.020
15. Lund-Pero M, Jeppson B, Arneklo-Nobin B, Sjögren HO, Holmgren K, Pero RW. Non-specific steroidal esterase activity and distribution in human and other mammalian tissues. Clin Chim Acta. 1994;224(1):9-20. doi:10.1016/0009-8981(94)90116-3
16. Marwah A, Marwah P, Lardy H. Development and validation of a high-performance liquid chromatography assay for the quantitative determination of 7-oxo-dehydroepiandrosterone-3β-sulfate in human plasma. J Chromatogr B Biomed Sci Appl. 1999;721(2):197-205. doi:10.1016/S0378-4347(98)00474-5
17. Kaiman DS, Colker CM, Swain MA, Torina GC, Shi Q. A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults. Curr Ther Res. 2000;61(7):435-442. doi:10.1016/S0011-393X(00)80026-0
18. Zenk JL, Helmer TR, Kassen LJ, Kuskowski MA. The effect of 7-Keto NaturaleanTM on weight loss: A randomized, double-blind, placebo-controlled trial. Curr Ther Res. 2002;63(4):263-272. doi:10.1016/S0011-393X(02)80031-5
19. Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem. 2007;18(9):629-634. doi:10.1016/J.JNUTBIO.2006.11.008
20. Bobyleva V, Bellei M, Kneer N, Lardy H. The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Arch Biochem Biophys. 1997;341(1). doi:10.1006/ABBI.1997.9955
21. Hennebert O, Chalbot S, Alran S, Morfin R. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. J Steroid Biochem Mol Biol. 2007;104(3-5):326-333. doi:10.1016/j.jsbmb.2007.03.026
22. Weeks C, Lardy H, Henwood S. Preclinical toxicology evaluation of 3-acetyl-7-oxo-dehydroepiandrosterone (7-Keto DHEA). FASEB J. 1998;12:A4428. https://www.researchgate.net/publication/287827628_Preclinical_toxicology_evaluation_of_3-acetyl-7-oxo-dehydroepiandrosterone_7-Keto_DHEA.– LinkOpens in New Tab Accessed August 7, 2020.
23. Lardy H, Henwood SM, Weeks CE. An acute oral gavage study of 3beta-acetoxyandrost- 5-ene-7,17-dione (7-oxo-DHEA-acetate) in rats. Biochem Biophys Res Commun. 1999;254(1):120-123. doi:10.1006/bbrc.1998.9907
24. Henwood SM, Weeks CE, Lardy H. An Escalating Dose Oral Gavage Study of 3β-Acetoxyandrost-5-ene-7,17-dione (7-oxo-DHEA-acetate) in Rhesus Monkeys. Biochem Biophys Res Commun. 1999;254(1):124-126. doi:10.1006/bbrc.1998.9908