Anti-Aging Ultra Cream (Ascorbic Acid / Azelaic Acid / ALA / Estriol / Progesterone) (30 g)

As we get older, our skin naturally starts to lose its firmness, thickness, and ability to heal quickly. That’s where Anti-Aging Ultra Cream comes in. It’s made with carefully chosen ingredients that work together to help your skin feel smoother, look brighter, and stay youthful.

One of the stars of this cream is Vitamin C, which helps boost collagen—the stuff that keeps your skin firm—and protects it from damage caused by everyday stress. Alpha Lipoic Acid is a powerful antioxidant that helps reduce puffiness and fine lines while giving your skin a healthy glow.

The cream also includes Estriol, a gentle plant-based estrogen that helps your skin stay thick and elastic, and Progesterone, which can slow down signs of aging, especially during menopause.

Ascorbic Acid (Vitamin C)

Vitamin C is essential for building collagen — the protein that keeps skin, cartilage, bones, and connective tissue strong and healthy. It also helps repair tissues, supports blood vessel strength, and plays a role in the production of important hormones, neurotransmitters, and energy molecules.

Because vitamin C is also a powerful antioxidant, it helps fight free radicals, boosts immune defenses, and may improve the body’s ability to absorb and use iron. Topically, vitamin C helps support collagen production and tissue repair, which can reduce fine lines, promote skin firmness, and improve healing.

Studies also suggest vitamin C may lower the risk of heart disease, diabetes complications, strokes, and even help protect the brain and eyes when combined with other antioxidants.

Azelaic Acid

It works in several ways: it helps reduce bacteria linked to acne, soothes inflammation, and encourages normal skin cell turnover to keep pores clear.

It’s widely used to treat acne and rosacea because of its antibacterial and anti-inflammatory properties. It can also improve uneven skin tone, reduce dark spots, and smooth rough texture. Azelaic acid works by slowing the production of excess pigment and calming irritation, making it helpful for conditions like melasma, hyperpigmentation, and even certain skin cancers.

Unlike some acne treatments, it doesn’t affect oil production, which makes it gentler on the skin.

Alpha Lipoic Acid (ALA)

Alpha Lipoic Acid is a strong antioxidant naturally found in every cell of the body, where it helps produce energy. What makes it unique is that it’s both water- and fat-soluble, so it works throughout the body — including deep in skin cells.

Applied topically, ALA may reduce puffiness, redness, and uneven tone, minimize fine lines and enlarged pores, and improve overall radiance. It can also support circulation in the skin, giving a healthy glow. Because of its anti-inflammatory and antioxidant powers, ALA is often called a “universal antioxidant” for its ability to protect against many signs of aging.

Estriol

It helps boost collagen production, skin thickness, and elasticity — all of which decline with age, especially after menopause.

Unlike stronger estrogens, estriol mainly works at the skin level without significant effects throughout the body, making it ideal for topical use. By supporting collagen and hydration, it may help reduce wrinkles and restore a more youthful texture and firmness to skin.

Progesterone

It balances estrogen, helps regulate menstrual cycles, and supports pregnancy.

For skin, progesterone may help slow age-related changes, particularly those linked to menopause. It promotes firmness and elasticity, giving skin a more youthful look. When combined with estrogen therapy in women with an intact uterus, progesterone also provides protective benefits against endometrial overgrowth.

In topical skincare, progesterone is valued for helping restore balance, reduce thinning, and improve skin’s youthful appearance.

Safety & Precautions
Ascorbic Acid (Vitamin C)

Pregnancy & Breastfeeding

No evidence of harm when taken orally within recommended doses.

RDA for pregnant women should be followed.

Passes into breast milk; supplementation increases levels but is considered safe if kept within RDA.

Renal Risks

High doses may cause kidney damage (oxalate nephropathy) or kidney stones.

Higher risk in patients with kidney disease, history of stones, elderly, infants, or children under 2.

Monitor kidney function in at-risk patients.

G6PD Deficiency

Use reduced dose and monitor blood counts.

Iron Overload

May increase iron absorption and toxicity in hemochromatosis.

Limit intake to ≤500 mg/day in such patients.

Other Concerns

Some IV/oral preparations contain sodium → use caution in patients on sodium-restricted diets.

Rarely, very high doses linked to fatal arrhythmias in iron overload.

Can interfere with lab tests (e.g., glucose, bilirubin, leukocytes, stool occult blood tests). Labs should ideally be delayed 24–72 hours after infusion.

Azelaic Acid

Allergies

Avoid if allergic to propylene glycol or formulation ingredients.

Skin Type Caution

May cause hypopigmentation in patients with dark skin.

Application Warnings

Do not use with occlusive dressings.

Avoid contact with eyes, mouth, mucous membranes.

Do not apply to herpes labialis lesions (may worsen).

Pediatrics

Safety not established in children <12 (cream/gel).

Foam: not for use <18 years.

Asthma

May worsen symptoms (wheezing, dyspnea). Discontinue if asthma exacerbation occurs.

Estriol

Contraindicated in patients with:

Breast, ovarian, or endometrial cancer

History of clotting disorders, stroke, or thromboembolism

Coronary artery disease, hypertension

Dementia, migraines, seizure disorders

Endometriosis, uterine fibroids, gallbladder/liver disease

Hyperlipidemia, urinary incontinence

History of tobacco use

Progesterone

Cancer Risks

Contraindicated in patients with breast, ovarian, uterine, cervical, or vaginal cancers.

Not for unexplained vaginal bleeding.

Regular breast exams, mammograms, and monitoring are required.

Cardiovascular/Thromboembolic Risks

Contraindicated in patients with history of DVT, PE, stroke, MI.

Increases risk of clotting, stroke, and heart attack in postmenopausal women (per WHI trial).

Use lowest effective dose for shortest duration.

Avoid use for prevention of heart disease.

Other Contraindications

Liver disease/dysfunction

Pediatric/infant use not established; neonatal exposure can cause “gasping syndrome” due to benzyl alcohol.

Fertility

High doses of injection act as antifertility drugs, reversible after treatment stops.

Neurological/Mental Health

Use cautiously in patients with depression, migraines, or seizures (may worsen symptoms).

Metabolic/Other Risks

May reduce glucose tolerance (caution in diabetes).

Can affect lipid metabolism (caution in hyperlipidemia).

May cause fluid retention (caution in CHF, renal disease, asthma).

May cause dizziness → caution with driving/machinery.

Cognitive Risks in Elderly

Estrogen + progesterone therapy increases risk of dementia in women >65 (per WHIMS trial).

Should not be used to prevent cognitive decline.

⚠️ Safety & Side Effects – Ingredient Summary
Ascorbic Acid (Vitamin C)

Kidney risks: Large doses can cause kidney stones (oxalate, urate, or cystine type) → symptoms include flank or lower back pain. About 5% of high-dose users develop excess oxalate in urine. Risk higher in:

Patients with kidney disease

Patients on dialysis

History of kidney stones

Infants/children <2 years

GI issues: Oral doses >1 g/day may cause diarrhea, cramps, vomiting.

IV administration: Rapid infusion can cause faintness, nausea, flushing, dizziness, or headache. Must be infused slowly.

Blood risks: In G6PD-deficient patients, very high doses may trigger hemolytic anemia.

Dental effects: Overuse of chewable tablets may damage enamel, leading to cavities or tooth sensitivity.

Injection site: Pain or swelling possible with IV use.

Azelaic Acid

Common skin reactions (mild, often temporary):

Burning, stinging, tingling (1–6%)

Itching (1–5%)

Dry skin (<5%)

Redness, irritation, or rash (<2%)

Peeling, dermatitis, or swelling (<1%)

Skin pigmentation: May cause lightening in darker skin; rare cases of depigmentation or vitiligo.

Other rare reports: Excess hair growth, keratosis pilaris–like redness, worsening cold sores.

Post-marketing reports: Allergic reactions (angioedema, hives, facial swelling, eye inflammation), asthma worsening, iridocyclitis if accidentally enters eyes.

Alpha Lipoic Acid (ALA)

Adverse effects: None well-documented.

Drug interactions:

Alcohol: may reduce ALA’s effectiveness → avoid.

Diabetes meds: may enhance glucose-lowering effect → risk of hypoglycemia.

Calcium, magnesium, iron salts: interfere with absorption (take at different times if both needed).

Cisplatin: ALA may reduce its anticancer effect → monitor closely.

Progesterone

Common side effects:

Menstrual changes: irregular cycles, spotting, heavier or lighter flow, cramps, missed periods.

GI issues: nausea, bloating, abdominal pain, constipation/diarrhea.

Breast: tenderness, enlargement, nipple discharge.

Weight changes, headache, dizziness, fatigue, mood swings.

Vaginal use (gels/inserts): irritation, dryness, pain with sex, unusual discharge.

Fluid retention/edema: Can worsen heart or kidney disease.

Mood & CNS effects: Depression, anxiety, irritability, insomnia, migraines, tremors. Rare: seizures, fainting, suicidal thoughts.

Cardiovascular risks (esp. with HRT):

↑ Risk of DVT, pulmonary embolism, stroke, and heart attack (esp. in postmenopausal women using estrogen + progesterone).

Greatest risk in the first year, persists with ongoing use.

Cancer risks:

Linked to breast, endometrial, and ovarian cancers when combined with estrogen (HRT).

Unopposed estrogen raises endometrial cancer risk; adding progesterone reduces but doesn’t eliminate this.

Long-term HRT (5–10+ years) significantly raises risk.

Other post-marketing reports: hypertension, palpitations, congenital heart disease (rare), cleft palate/lip, liver damage (hepatitis, liver failure, jaundice).

Cognition & dementia: Combined estrogen + progesterone HRT increases risk of dementia in women >65 (per WHIMS trial). Not protective for memory.

Ascorbic acid
Although there are no data on ascorbic acid injection in human pregnancy to guide a medication-related risk of negative developmental outcomes, use of oral Ascorbic acid has been used during pregnancy and no negative developmental consequences have been documented. A metaanalysis of randomized trials on pregnant women taking oral vitamin C dosages ranging from 500 to 1,000 mg/day (2.5 to 5) times the advised daily intravenous dosage, respectively, between the ninth and sixteenth week of pregnancy Preterm delivery, hypertension caused by pregnancy, or preterm premature rupture of membranes were seen against placebo; follow the US Recommended Dietary Allowances (RDA) for pregnant women receiving ascorbic acid therapy.

Azelaic acid
Designated FDA pregnancy risk category B, azelaic acid’s oral administration causes embryotoxic effects in animal studies but no teratogenic changes were found.

Progesterone
Certain progesterone supplements are meant especially for use to offer luteal support early in pregnancy. Oral, vaginal, or in utero progesterone administration investigations on animals have not revealed any indications of fetal damage. Early pregnancy can be supported with progesterone vaginal gel as part of an Assisted Reproductive Technology (ART) program; should pregnancy occur, the gel is Usually lasting 10 to 12 weeks until placental progesterone production is sufficient to sustain the pregnancy. Progesterone vaginal inserts are employed for up to ten weeks in ART as well. Only under the direction of an ART expert during early pregnancy should progesterone be utilized. Particularly in high-risk singleton pregnancies, data indicate that vaginal progesterone is effective in avoiding preterm delivery and related newborn problems; administration generally starts at Starts 16 to 24 weeks gestation and goes through 34 weeks gestation. Progesterone should be avoided if there is ectopic pregnancy, missed/incomplete abortion, or während diagnostic tests for pregnancy. Indicated only in postmenopausal women, progesterone capsules are hence especially contraindicated for usage throughout pregnancy.

Store this medication in its original container at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

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