Hydroxocobalamin (Vitamin B12) Injection (10 mL Vial)

It works by replenishing Vitamin B12 in the body, which is crucial for nerve function, red blood cell production, and DNA synthesis.

Vitamin B12 is essential for the formation of red blood cells and the proper functioning of the nervous system. Hydroxocobalamin works by binding to B12 receptors, restoring normal levels and promoting the production of healthy blood cells.

Contraindications & Precautions
⦁ Contraindications: Hypersensitivity to Hydroxocobalamin or cobalt.
⦁ Precautions: Use cautiously in patients with Leber’s disease (a hereditary optic neuropathy), and those with renal or hepatic impairment.
Interactions
⦁ Chloramphenicol: May interfere with the effects of Hydroxocobalamin on blood cell production.
⦁ Folic acid: High doses of folic acid can mask the symptoms of Vitamin B12 deficiency, but not the underlying neurological damage.

Medications known to cause bone marrow suppression (e.g., myelosuppressive anticancer agents) associated with Bacillus Calmette-Guerin vaccine may result in a blunted or inhibited reaction to hydroxocobalamin, vitamin B12 treatment.

Limited evidence from case studies suggests that chloramphenicol, a bacteriostatic antibiotic, could interact with the red blood cell response to supplementary vitamin B12. in a few patients by interrupting erythrocyte maturation.

Although usually helpful for cancer patients, it has been seen to impede chemotherapy by exhaustion of extracellular cysteine in tandem with ascorbate.

Used to treat diabetes, metformin might impact the intestinal cells engaged in intrinsic factor metabolism and calcium-dependent absorption of vitamin B12 leading reduced assimilation of the vitamin. Other causes, such more bacterial overgrowth, may also trigger it.

Absorption of B12 can be influenced by histamine H2 receptor antagonists taken for peptic ulcer disease and proton pump inhibitors taken for gastroesophageal reflux disease. And it is advisable to check the vitamin levels in patients using them over extended periods. Antimetabolites for B12 known as antineoplastics can lessen its hematological reaction.

When combined in solution with diazepam, dobutamine, dopamine, fentanyl, nitroglycerin, pentobarbital, propofol, and thiopental, hydroxocobalamin has been discovered to be physically unstable. It is chemically at odds with ascorbic acid, sodium nitrite, and sodium thiosulfate.

Adverse Reactions / Side Effects
⦁ Common: Pain or irritation at the injection site, mild diarrhea, headache, and skin rash.
⦁ Serious: Anaphylaxis, pulmonary edema, or hypokalemia (rare, but can occur with large doses).

Pregnancy & Breastfeeding
⦁ Pregnancy: Safe to use during pregnancy; essential for fetal development.
⦁ Breastfeeding: Safe to use while breastfeeding, as it passes into breast milk in small amount

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond-use date. Do not flush unused medications or pour them down a sink or drain.

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