Prescription medication sertraline might help with post-traumatic stress disorder (PTSD), panic disorder, obsessive-compulsive disorder (OCD), or depression. Selective serotonin reuptake inhibitor (SSRI) is one of these, which could raise the brain’s supply of a neurotransmitter called serotonin. Mood, emotions and behavior are mostly controlled by serotonin; sertraline may aid to increase serotonin activity in by inhibiting the reabsorption of serotonin (reuptake). Therefore supporting the brain with symptoms of depression, worry, and other associated illnesses.
Sertraline may need several weeks to show its whole therapeutic benefits; thus it is imperative for patients to keep taking the medicine exactly as directed. even if their symptoms do not seem to be quickly better. Sudden cessation of sertraline could result in withdrawal symptoms; thus, it is imperative to gradually lower the dose under the direction of a healthcare practitioner.

Sertraline works by blocking the reabsorption (reuptake) of serotonin, a neurotransmitter responsible for regulating mood and emotions. By preventing serotonin from being reabsorbed too quickly, it remains available in the brain’s communication pathways for a longer time, improving nerve signaling and mood stability. This action helps alleviate symptoms of depression and anxiety while supporting a more balanced mental state.

Sertraline should not be used by individuals with known hypersensitivity to the drug or its components. It is also contraindicated in patients taking monoamine oxidase inhibitors (MAOIs) or within two weeks of discontinuing such treatment, as it may lead to serious reactions. Caution is advised for individuals with liver or kidney problems, a history of bipolar disorder, seizures, or suicidal thoughts. Regular monitoring by a healthcare provider is essential during treatment.

Sertraline may interact with various medications including MAO inhibitors, blood thinners, nonsteroidal anti-inflammatory drugs (NSAIDs), and other antidepressants. Combining it with substances that influence serotonin levels can increase the risk of serotonin syndrome, a potentially life-threatening condition. Alcohol should be avoided as it may worsen side effects or reduce the effectiveness of the medication. Always consult a doctor before adding new medications or supplements.

Common side effects may include nausea, dizziness, dry mouth, sleep disturbances, sweating, or changes in appetite. Some people experience increased anxiety, restlessness, or mild headaches during the early phase of treatment. Rare but serious side effects include suicidal thoughts, severe mood swings, seizures, or serotonin syndrome. Any unusual symptoms should be reported to a healthcare provider immediately.

The use of sertraline during pregnancy should be carefully evaluated, as it may pose risks to the developing fetus. It is generally prescribed only when the benefits outweigh the potential harms. During breastfeeding, small amounts of the medication may pass into breast milk, possibly affecting the infant. Mothers should consult their healthcare provider before using the medication and discuss possible alternatives or close monitoring.

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

1. Singh HK, Saadabadi A. Sertraline. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547689/– LinkOpens in New Tab
2. “Sertraline.” MedlinePlus, U.S. National Library of Medicine, medlineplus.gov/druginfo/meds/a697048.html