Sildenafil / Apomorphine HCl Troche (Each)

Sildenafil / Apomorphine HCl Troches ek special combination therapy hai jo erectile dysfunction (ED) aur sexual performance issues ke treatment ke liye use hoti hai. Troche form hone ki wajah se ye muh mein rakhte hi dheere-dheere ghul kar directly blood mein absorb ho jati hai, jisse iska asar jaldi shuru ho jata hai. Sildenafil blood flow ko behtar banata hai, jabki Apomorphine HCl nervous system par kaam karke sexual arousal aur motivation mein madad karta hai. Dono milkar sharirik aur mansik dono star par support dete hain.

Is dawa mein do alag-alag mechanism ka mel hai. Sildenafil, PDE5 enzyme ko rok kar blood vessels ko relax karta hai, jisse penis mein blood flow badhta hai aur erection ko support milta hai. Apomorphine HCl dopamine receptors ko stimulate karta hai, jo dimaag ke reward aur arousal system ko activate karta hai. Isse sexual desire mein sudhar hota hai aur performance anxiety kam hoti hai. Dono milkar sexual response ko behtar banane mein madadgar sabit hote hain.

Yeh dawa har kisi ke liye safe nahi hai. Agar aapko heart disease, low ya high blood pressure, stroke, ya kidney-liver sambandhit gambhir samasya hai to isse lene se pehle doctor se salah zarur leni chahiye. Nitrate ya vasodilator medicines ke saath is dawa ka use blood pressure ko khatarnak tareeke se kam kar sakta hai. Parkinson’s disease ya hormonal imbalance wale logon ko bhi is dawa ko saavdhani se lena chahiye. Kisi bhi dawa ke saath interaction hone ka khatra ho to apne doctor ko puri jaankari den.

Aksar log ise achhi tarah tolerate kar lete hain, lekin kuch logon mein side effects ho sakte hain. Sir dard, muh ka sookhna, halka chakkar aana, chehre ka lal hona, ya pet mein jalan aam lakshan hain. Apomorphine HCl ke karan kuch logon mein neend mein gadbad, ghabrahat ya mood swings bhi ho sakte hain. Rare cases mein chest pain, allergic reactions, ya prolonged erection ho sakta hai, jiske liye turant medical madad lena zaruri hai.

Yeh dawa pramukh roop se purushon ke liye design ki gayi hai, isliye pregnancy ya breastfeeding mein iska istemal seemit hai. Agar kisi mahila ko galti se iska contact ho jaye ya kisi vishesh medical condition mein iski zarurat ho, to bina doctor ki salah ke iska upyog nahi karna chahiye. Is dawa ka garbh ya shishu par kya prabhav ho sakta hai, isse lekar paryapt clinical data uplabdh nahi hai.

Store this medication in its original container at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

1. Goldstein, I., Burnett, A., Rosen, R.C., Park, P.W., Stecher, V.J.,” The Serendipitous Story of Sildenafil: An Unexpected Oral Therapy for Erectile Dysfunction”, Sexual Medicine Reviews, vol.7 issue 1, pp. 115-128. 2019. Available: https://www.sciencedirect.com/science/article/pii/S2050052118300830?via%3Dihub– LinkOpens in New Tab
2. McCullough, A.R., “Four-Year Review of Sildenafil Citrate”, Reviews in Urology, vol.4 supp 3, S26 – S38. 2002. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1476025/– LinkOpens in New Tab
3. “Sildenafil citrate”, Prescribers Digital Reference. Available: https://www.pdr.net/drug-summary/?drugLabelId=Viagra-sildenafil-citrate-471– LinkOpens in New Tab
4. “Sildenafil”, Drug Bank. Available: https://go.drugbank.com/drugs/DB00203– LinkOpens in New Tab
5. Dastjerdi, M.V., Hosseini, S., Bayani, L., “Sildenafil citrate and uteroplacental perfusion in fetal growth restriction”, Journal of Research in Medical Sciences, vol.17 issue 7, pp.632-636. 2012. Available: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685778/– LinkOpens in New Tab
6. Apokyn and Apokyn Pen (apomorphine) injection package insert. Louisville, KY: US WorldMeds LLC; 2020 Apr.
7. Kynmobi (apomorphine hydrochloride) sublingual film. Marlborough, MA: Sunovion Pharmaceuticals, Inc.; 2020 May.
8. Bowron A. Practical considerations in the use of apomorphine injectable. Neurology 2004;62:S32-36.
9. “Sildenafil citrate”, Prescibers’ Digital Reference. Available: https://www.pdr.net/drug-summary/?drugLabelId=Viagra-sildenafil-citrate-471– LinkOpens in New Tab
10. Smith, B.P., Babos, M., “Sildenafil”, StatPearls. 2020. Available: https://www.ncbi.nlm.nih.gov/books/NBK558978/– LinkOpens in New Tab
11. Roden, DM. Drug-induced prolongation of the QT interval. New Engl J Med 2004;350:1013-22.
12. Crouch MA, Limon L, Cassano AT. Clinical relevance and management of drug-related QT interval prolongation. Pharmacotherapy 2003;23:881-908.
13. van Noord C, Eijgelsheim M, Stricker BH. Drug- and non-drug-associated QT interval prolongation. Br J Clin Pharmacol 2010;70(1):16-23.
14. Woosley RL, Heise CW, Gallo T, et al. QTFactors List. Oro Valley, AZ: AZCERT, Inc.; Accessed March 31, 2020. Available on the World Wide Web at: https://crediblemeds.org/ndfa-list/– LinkOpens in New Tab
15. Health Care Financing Administration. Interpretive Guidelines for Long-term Care Facilities. Title 42 CFR 483.25(l) F329: Unnecessary Drugs. Revised 2015.
16. Holdsworth JD, Furness RM, Roulston G. A comparison of apomorphine and stomach tubes for emptying the stomach before general anaesthesia in obstetrics. Br J Anaesth 1974;46:526-9.