Initially, 10 mg total daily testosterone applied to hairless skin patches; compounded preparations allow for microadjustment, though. Providers could specify 1 mg/mL concentration and tell one pump actuation administering 0.5 mL (0.5 mg) twice daily, titrating up in weekly 1 mg/mL increments. on hemoglobin levels, symptom response, and trough serum testosterone taken 12 hours after application.

Higher concentrations (e.g., 100 mg/mL) provide patients needing significant replacement but wanting to reduce skin surface coverage smaller application volumes; nevertheless, increasing concentration can locally increase DHT conversion; therefore, alternate anatomical sites or splitdose regimens may balance efficacy against androgenic cutaneous effects.

Endogenous testosterone is produced by some cell types in the testis, ovary, and adrenal cortex. Testosterone is used in the therapy of either congenital or acquired hypogonadism. Testosterone is the top exogenous androgen for postmenopausal women palliative treatment of breast cancer. Because of their unauthorized usage, anabolic steroids—which are testosterone derivatives—have become classified as controlled substances. Testosterone, along with several anabolic steroids, was classified as a restricted drug in 1991. Approved by the FDA in 2000 for the therapy of hypogonadism, a condition often Causes mood, energy, sexual dysfunctions, as well as several injury-related ailments like those seen in major burn and car victims. A highly popular form of testosterone called AndroGel is marketed under a few lesser known brand/trade names around the world—most especially Testogel manufactured in Several generic versions often sold.

The areas of the target body for the transdermal delivery method of testosterone cream are the same as or quite similar to those for injections and other testosterone administration techniques. More specifically, like testosterone injections do, testosterone cream absorbs best when applied to heavily muscled body regions. Because more testosterone-absorbing capillaries at When there is more muscle, testosterone can get into the blood more quickly at the application site.

Endogenous testosterone allows sexual development to take place throughout life in all phases of development. From cholesterol, it’s produced synthetically. Males’ development from generality to majority depends much on androgens. They’re critical throughout puberty. Women also cache small quantities of testosterone from their ovaries. The androgen release by the adrenal cortex can not support manly fornication.

Through a negative feedback medium, high androgen tube situations suppress gonadotropin- releasing hormone( which lowers endogenous testosterone), luteinizing hormone, and follicle- stimulating hormone. Testosterone also affects calcium equilibrium, blood sugar control, and erythropoietin conflation. Testosterone is enzymatically changed to 5 alphadihydrotestosterone as it enters cells; this creates a approximately bound complex with cytosolic receptors. Androgen exertion results from the steroid receptor complex’s induction of launch recap and cellular changes in the nexus.

Endogenous androgens constantly stimulate RNA polymerase, which increases protein product. The prostate, seminal vesicle, penis, and scrotum develop and develop. Well as these proteins control other rudiments of conventional manly sexual development. Androgens encourage a strong rise in muscular growth and development throughout Puberty, together with a stirring of body fat, also affects the larynx and oral cords. Development and the preservation of spermatogenesis are supported by exogenous androgens in the absence of endogenous androgens.

Your croaker needs to know if you have any of the ensuing conditions bone cancer, sleep apnea, diabetes, heart complaint, order complaint, liver complaint, lung complaint, prostate cancer or blowup, any unusual or antipathetic responses to testosterone or other specifics, being pregnant or trying to come pregnant, or breastfeeding. While using testosterone, your croaker will need to have frequent bloodwork taken. utmost athletic associations prohibit using this medicine on athletes.

Since topical gels and results are constantly ignitable , using any topical gel or result expression of testosterone should be done without being exposed to fire, honey, or cigarette smoking.

manly cases with prostate cancer or bone cancer should n’t use testosterone since it can promote the conformation of nasty towel. Prostatic hypertrophy cases should be treated precisely because androgen remedy may complicate the condition’s signs and symptoms and raise the possibility of cancer developing. Prior to beginning testosterone relief drug, senior cases and other cases with clinical or demographic traits known to be linked to an elevated threat of prostate cancer should be assessed for the complaint’s actuality. Prostate cancer surveillance in cases entering testosterone remedy ought to follow being guidelines for eugonadal men. Age- related hypogonadism alone in senior cases or andropause are n’t advised for testosterone relief remedy because there’s shy substantiation of its safety and effectiveness.( 1) likewise, due to a dearth of senior actors in controlled trials, the effectiveness and long- term safety of testosterone topical result in cases aged than 65 have n’t been established. The Beers Criteria state that testosterone is a potentially unhappy medicine( PIM) for senior people and that it should be avoided since it may beget cardiac issues and is contraindicated in cases of prostate cancer. Use for moderate to severe hypogonadism is respectable in the opinion of the Beers expert panel.

Cases with liver complaint or malfunction should be given testosterone with caution due to dropped medicine concurrence and an increased threat of medicine buildup. also, edema brought on by sodium and water retention may develop while taking androgens for treatment. In individualities with hepatic complaint, renal complaint similar as nephritis and nephrosis, preexisting edema, or cardiac complaint similar as heart failure, coronary roadway complaint, and myocardial infarction( MI). Further, anyhow ofpre-existing heart complaint, exploration is being done into the implicit link between testosterone operation and an increased threat of serious cardiovascular events. Adult manly cases with an average age of 60 were included in an experimental study at the U.S. Veterans Affairs medical system. Within the larger group, 1223 guys passed testosterone remedy after a standard of 531 days had passed since coronary angiography; 7486 males did not. In the three times following coronary angiography, individualities taking testosterone remedy endured a serious and/ or fatal cardiovascular event at a rate of 25,7 compared to cases not entering remedy at a rate of 19,9.( MI, stroke, death). The prevalence of acutenon-fatal MI following a first testosterone tradition was examined in a alternate experimental exploration( n = 55,593) in both youngish( = 55 times) and aged(> = 65 times) adult males. There was a2-fold increase in MI threat among aged men during the 90- day window, and there was a 2- to3-fold increase in MI threat among youngish men with a history of cardiac complaint. youngish men without a history of heart complaint, in comparison, did n’t parade an elevated threat.( 5) In response to these findings, the FDA said in the morning of 2014 that it’ll look into any eventuality associations between testosterone remedy and serious cardiovascular events. But healthcare interpreters are recommended to precisely examine whether the implicit troubles overweigh the anticipated benefits of treatment. When the review is over, the FDA will advertise its final results and suggestions.

In cases with apnea threat factors including rotundity or habitual respiratory complaint, testosterone esters remedy for hypogonadal males may make the condition worse. also, it’s unknown if testosterone topical result and intranasal gel are safe and effective in treating fat men with BMIs lesser than 35 kg/ m2.

Cases entering testosterone should routinely have their hemoglobin and hematocrit situations checked to look for polycythemia.

Due to the implicit detriment it could beget to the developing fetus, testosterone is n’t recommended during gestation( FDA gestation threat order X). When getting testosterone remedy, women who are able of having children should use dependable contraception. There should be no specific reason to give the particulars to women during labor or obstetric delivery because testosterone is n’t employed throughout gestation; safety and efficacity in these circumstances have n’t been shown.

Certainly! Here’s a humanized, easy-to-understand summary of testosterone therapy side effects and safety information, expanded to about 700 words:

Understanding the Side Effects and Safety of Testosterone Therapy

Testosterone therapy is often prescribed to men who have low testosterone levels, helping to improve energy, mood, muscle mass, and sexual function. However, like any medication, testosterone can cause side effects, some of which may be serious. It’s important to understand these potential effects and to work closely with your healthcare provider to monitor your health during treatment.

Feminizing Effects in Men

One of the less expected side effects of long-term testosterone therapy is something called feminization. This happens because some of the testosterone in the body can be converted into estrogen, the female hormone. Men with liver problems are more likely to experience this. Symptoms include breast tenderness and enlargement, medically known as mastalgia and gynecomastia. While these changes can be concerning, the good news is that they are usually reversible once testosterone treatment is stopped.

Testosterone therapy also signals the brain to reduce its own production of testosterone. At high doses, it can suppress sperm production, which may affect fertility.

Sexual Side Effects

Testosterone can affect sexual desire in different ways. Some men find their libido increases, while others may notice a decrease. Rarely, especially in older men or those taking high doses, testosterone can cause prolonged or unwanted erections, a condition called priapism. This can be painful and requires immediate medical attention.

Prostate Health

Testosterone can cause the prostate gland to enlarge, a condition called benign prostatic hyperplasia (BPH). This is more common in older men and can lead to urinary symptoms such as frequent urination, difficulty starting or stopping urine flow, weak stream, or urgency. Testosterone therapy may also raise prostate-specific antigen (PSA) levels, a marker doctors use to screen for prostate cancer.

Because of these risks, men on testosterone should have regular prostate exams and PSA blood tests. If you experience symptoms like pain during urination, blood in urine, or urinary urgency, contact your healthcare provider promptly. In rare cases, testosterone therapy has been linked to prostate cancer, so ongoing monitoring is essential.

Effects in Women

Women who use testosterone may develop male-like features such as acne, excess facial or body hair, a deeper voice, and changes in menstrual cycles. These effects often improve if treatment is stopped early, but long-term use can cause permanent changes. Testosterone can also disrupt the menstrual cycle, causing missed or irregular periods.

Because testosterone can harm a developing fetus, pregnant women or women who may become pregnant should avoid exposure, including accidental contact with topical testosterone products.

Skin Reactions

Testosterone gels, patches, and topical solutions can cause skin irritation where applied. Many people experience redness, itching, or burning. Sometimes, blisters or more severe skin reactions can occur, especially if the patch is placed on bony areas or areas under pressure during sleep or sitting. Using mild steroid creams like hydrocortisone after removing the patch can help reduce irritation. Acne and oily skin are also common side effects.

Fluid Retention and Blood Pressure

Testosterone can cause the body to retain fluid, leading to swelling and weight gain. This is usually mild but can be more serious in people with heart, kidney, or liver problems. Testosterone may also raise blood pressure in some men, so regular monitoring is important.

Heart and Blood Vessel Risks

There is ongoing research about whether testosterone increases the risk of heart attacks, strokes, or other serious heart problems. Some studies suggest a higher risk, especially in older men or those with existing heart disease. However, the FDA has not made a final conclusion. Doctors carefully weigh the benefits and risks before prescribing testosterone.

Liver Health

Liver problems are rare but possible, especially with certain types of testosterone or when abused.

Mood and Nervous System Effects

Some men report headaches, mood swings, irritability, anxiety, depression, or difficulty sleeping while on testosterone. These symptoms vary and should be discussed with your healthcare provider.

Digestive and Other Side Effects

Testosterone can cause nausea, diarrhea, back pain, and fatigue in some people. Other less common effects include dizziness, increased sweating, and changes in taste or mouth irritation, especially with buccal (gum) testosterone products.

Bone and Calcium Effects

Testosterone can affect bone health. In some cases, it may cause bone loss or worsen high calcium levels, especially in patients with certain cancers. Regular monitoring may be needed.

Changes in Blood Counts

Symptoms of thickened blood include dizziness, headaches, unusual bleeding, or redness of the skin. Your doctor will monitor your blood regularly to avoid complications.

Blood Clot Risks

Testosterone use has been linked to an increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE), which are serious conditions involving blood clots in the legs or lungs.

Injection Site Reactions

If you receive testosterone injections, you may experience pain, redness, swelling, or irritation at the injection site. Rarely, serious allergic reactions or breathing problems can occur shortly after injection, especially with certain formulations. Doctors usually monitor patients for a short time after injections to manage any reactions.

Sleep Apnea

Testosterone therapy may worsen sleep apnea, a condition where breathing stops briefly during sleep. This is especially a concern for men who are overweight or have lung disease.

Nasal Testosterone Side Effects

Most symptoms are mild, but if they persist, talk to your doctor.

What to Know About Testosterone Therapy and Its Side Effects

When men use testosterone therapy for a long time, some may experience changes that seem more “feminine.” This happens because testosterone can partly turn into estrogen, the female hormone. Men with liver problems are more likely to notice breast tenderness or enlargement. These effects usually go away if the treatment is stopped.

Testosterone therapy can also reduce the body’s own hormone production, which may lower sperm count and affect fertility, especially at higher doses.

Sexual side effects vary. Some men find their sex drive increases, while others may notice a decrease. Older men or those taking high doses might experience prolonged or unwanted erections, which need prompt medical attention.

Testosterone can cause the prostate gland to grow larger, especially in older men. This can lead to urinary problems like frequent urination, difficulty starting or stopping, or a weak stream. Testosterone may also raise PSA levels, a marker doctors use to check prostate health. Regular prostate exams and PSA tests are important during treatment. If you notice symptoms like pain or blood in urine, tell your doctor right away.

Women using testosterone may develop male-like features such as acne, excess hair growth, a deeper voice, and changes in their menstrual cycle. These effects often improve if treatment is stopped early but can become permanent with long-term use. Pregnant women or those trying to conceive should avoid exposure to testosterone, including accidental contact with gels or creams.

This can include redness, itching, burning, or rash. Sometimes blisters or more serious skin reactions occur, especially if patches are placed on bony areas or areas under pressure. Mild steroid creams can help reduce irritation.

This is usually mild but can be more serious in people with heart, kidney, or liver problems.

There is ongoing research about whether testosterone increases the risk of heart attacks or strokes. Some studies suggest a higher risk in older men or those with heart disease, but the FDA has not made a final conclusion. Doctors carefully weigh the benefits and risks before prescribing testosterone.

Other side effects can include headaches, mood changes, nausea, diarrhea, and fatigue. Testosterone can also increase red blood cell production, which thickens the blood and may increase the risk of blood clots.

Testosterone injections can cause pain or swelling at the injection site. Rarely, serious allergic reactions or breathing problems can occur shortly after injection, so doctors usually monitor patients for a short time after shots.

Testosterone therapy may worsen sleep apnea, especially in men who are overweight or have lung disease.

Testosterone is not advised during pregnancy (FDA pregnancy risk category X) because of the possible damage it might do to the developing fetus. Women who may have children undergoing testosterone therapy should utilize dependable birth control. There should be no particular justification for giving the products to women in labor or obstetric delivery since testosterone is not used during pregnancy; safety. Moreover, efficacy in these conditions has not been proven.

In nursing moms, testosterone topical solutions, transdermal patches, and gels are not recommended. One should also avoid other testosterone treatments when breastfeeding. Regarding the distribution of testosterone in breastmilk and whether exposure would surpass amounts typically present in human milk, doubt exists. Substantial nursing exposure to this androgen could have adverse infant androgenic effects, and the medicine may also obstruct the mother from beginning her milk supply correctly. Traditionally, auxiliary measures to suppress lactation included testosterone/androgens. In lactating women taking testosterone treatment, alternative means of breastfeeding are advised.

Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

1. “1.DELATESTRYL (Testosterone Enanthate Injection, USP) package insert. Lexington, MA: Indevus Pharmaceuticals, Inc.; 2007 July.
2. Axiron (testosterone) topical solution, package insert. Indianapolis, IN: Lilly USA, LLC; 2011 Dec.
3. The American Geriatrics Society 2012 Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 2012;60:616-31.
4. Vigen R, O’Donnell CI, Baron AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013;310:1829-1836.
5. WD Finkle, S Greenland, GK Ridgeway, et al. Increased Risk of Non-Fatal Myocardial Infarction Following Testosterone Therapy Prescription in Men. DOI: 10.1371/journal.pone.0085805
6. FDA Medwatch – FDA evaluating risk of stroke, heart attack and death with FDA-approved testosterone products. Retrieved January 31, 2014. Available on the World Wide Web https://www.fda.gov/Drugs/DrugSafety/ucm383904.htm– LinkOpens in New Tab
7. Natesto (testosterone) nasal gel package insert. Durants, Christ Church Barbados: Trimel BioPharma SRL; 2014 May.
8. (testosterone gel) package insert. Malvern, PA: Auxilium Pharmaceuticals, Inc.; 2010 Apr.
9. Androderm (testosterone transdermal system) package insert. Corona, CA: Watson Pharma, Inc.; 2014 Jun.
10. Androgel (testosterone gel) package insert. Marietta, GA: Solvay Pharmaceuticals, Inc.; 2012 Sept.
11. Striant (testosterone buccal system) package insert. Livingston, NJ: Columbia Laboratories, Inc.; 2014 Mar.
12. Fortesta (testosterone) gel, package insert. Chadds Ford, PA: Endo Pharmaceuticals Inc.; 2010 Dec.
13. Aveed (testosterone undecanoate Injection) package insert. Malvern, PA: Endo Pharmaceuticals Solutions Inc.; 2014 Mar.
14. DEPO-TESTOSTERONE (testosterone cypionate) injection, package insert. New York, NY: Pharmacia & Upjohn Co.; 2006 Sept.
15. Kochenour NK. Lactation suppression. Clin Obstet Gynecol. 1980;23:1045-1059.
16. Testim (testosterone gel) package insert. Malvern, PA: Auxilium Pharmaceuticals, Inc.; 2010 Apr.
17. Krauser JA, Guengerich FP. Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps. J Biol Chem 2005;280:19496—506.
18. Barnes KM, Dickstein B, Cutler GB Jr, et al. Steroid transport, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells. Biochemistry 1996;35:4820—7.
19. Wells PS, Holbrook AM, Crowther NR et al. Interaction of warfarin with drugs and food. Ann Intern Med 1994;121:676—83.
20. Goffin E, Pirson Y, Geubel A, et al. Cyclosporine-methyltestosterone interaction. Nephron 1991;59:174—5.
21. Borras-Blasco J, Rosique-Robles JD, Peris-Marti J, et al. Possible cyclosporin-danazol interaction in a patient with aplastic anaemia. Am J Hematol 1999;62:63—4.
22. Moller BB, Ekelund B. Toxicity of cyclosporine during treatment with androgens. N Engl J Med 1985;313:1416.
23. Ross WB, Roberts D, Griffin PJ, et al. Cyclosporin interaction with danazol and norethisterone. Lancet 1986;1:330.
24. Androgel® (testosterone gel) package insert. Montrogue, France: Laboratories Besins International; 2005 Aug.
25. Zoladex® (goserelin acetate) package insert. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2003 Dec.
26. Viadur® (leuprolide implant) package insert. Westhaven, CT: Bayer Pharmaceuticals; 2002 May.
27. Humatrope™ (somatropin);package insert. Indianapolis, IN: Eli Lilly and Company; 2003 Jul.
28. Androderm® (testosterone transdermal system) package insert. Corona, CA: Watson Pharma, Inc.; 1999 Jan.
29. Propecia® (finasteride) package insert. Whitehouse Station, NJ: Merck & Co., INC.; 2003 Oct.
30. Avodart™ (dutasteride) package insert. Research Triangle Park, NC: GlaxoSmithKline; 2005 May.
31. Robbers JE, Tyler VE. Tyler’s Herbs of Choice: the Therapeutic Use of Phytomedicinals. Binghamton NY: Haworth Herbal Press, Inc.; 1999.
32. German Commission E. Saw Palmetto berry, Sabal fructus, monograph Published March 2, 1989 and revised January 17, 1991. In: Blumenthal, M et al ., eds. The complete German Commission E Monographs -Therapeutic Guide to Alternative Medicines. Bosto
33. Lazar JD, Wilner KD. Drug interactions with fluconazole. Rev Infect Dis 1990;12:S327—33.
34. Hansten P, Horn J. The Top 100 Drug Interactions: A Guide to Patient Management. includes table of CYP450 and drug transporter substrates and modifiers (appendices). H & H Publications, LLP 2014 edition.
35. Boyanov MA, Boneva Z, Christov VG. Testosterone supplementation in men with type 2 diabetes, visceral obesity, and partial androgen deficiency. Aging Male 2003;6:1—7.
36. Kapoor D, Goodwin E, Channer KS, et al. Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity, and hypercholesterolaemia in hypogonadal men with type 2 diabetes. Eur J Clin Endocrinol 2006; 154:899—90
37. Hobbs CJ, Jones RE, Plymate SR. Nandrolone, a 19-nortestosterone, enhances insulin-independent glucose uptake in normal men. J Clin Endocrinol Metab 1996; 81:1582—5.
38. Corrales JJ, Burgo RM, Garcia-Berrocal B, et al. Partial androgen deficiency in aging type 2 diabetic men and its relationship to glycemic control. Metabolism 2004;53:666—72
39. Lee CH, Kuo SW, Hung YJ, et al. The effect of testosterone supplement on insulin sensitivity, glucose effectiveness, and acute insulin response after glucose load in male type 2 diabetics. Endocrine Res 2005;31:139—148.
40. Cohen JC, Hickman R. Insulin resistance and diminished glucose tolerance in powerlifters ingesting anabolic steroids. J Clin Endocrinol Metab 1987;64:960—3.
41. Aldercreutz H, Mazur W. Phyto-estrogens and western diseases. Annals of Medicine 1997;29:95—120.
42. Ranexa (ranolazine extended-release tablets) package insert. Foster City, CA: Gilead Sciences, Inc. 2013 Dec.
43. Letairis™ (ambrisentan) package insert. Foster City, CA: Gilead Sciences, Inc; 2008 Oct.
44. Pradaxa (dabigatran) package insert. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2015 Jan.
45. Gilotrif (afatinib) package insert. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc; 2013 Nov.
46. Androgel 1.62% (testosterone gel) package insert. North Chicago, IL: Abbott Laboratories; 2014 Nov.
47. Naik BS, Shetty N, Maben EVS. Drug-induced taste disorders. European Journal of Internal Medicine 2010; 21:240-243.”